CBD and the brain are destined for friendship, and many studies with scientific data support this relationship’s cognitive benefits. Whereas THC offers a sensational high, CBD is a non-psychoactive chemical compound that helps mental balance. As the cooler, darker months of the year loom ahead, it’s imperative to pay attention to our mental health.

So, let’s discuss how CBD affects the brain.

CBD and serotonin are a match made in heaven. Serotonin is a neurotransmitter responsible for emotion regulation, stress, and mood. If low in serotonin, this may result in higher levels of stress, anxiety, depression, mood swings, loss of appetite, and more. Basically, it’s not fun.

Enter CBD.

CBD interacts with the body’s endocannabinoid system (ECS) when consumed. The ECS is made up of neurotransmitters and acts as a bridge between the brain and the body. This is where we can find serotonin and dopamine receptors ready for action. The cannabinoid receptors bind themselves to the serotonin 1A receptors, altering serotonin levels, and helping regulate the nervous system. This allows the benefits of CBD to jump into action; cueing the mellowing effects of peace of mind.

So, what does this mean in plain English?

This means that CBD may help improve our mental well-being. Without stress, anxiety, and depression clouding our minds, we can focus on making the best out of life.

But CBD’s effect on the brain goes even deeper than improving our mental state.

CBD’s relationship with serotonin 1A receptors may also help with nausea from chemotherapy, neuropathic pain, and schizophrenia. Furthermore, studies find that CBD helps treat seizures, epilepsy, and neuropsychiatric disorders. In 2018, Epidiolex was approved by the FDA as a CBD-based treatment for Dravet Syndrome and Lennox-Gastaut syndrome (two syndromes that struggle with epilepsy) for patients aged two and up. As more research and clinical studies on the benefits of CBD come to light, we look forward to future treatment discoveries.


Always remember that cannabis consumption differs from person to person. Be mindful of your dosing and consult your doctor if you’re uncertain whether CBD is right for you.



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Bergamaschi M. M. et al. Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naive Social Phobia Patients. Neuropsychopharmacology (2011); 36(6): 1219-1226. Published online in February 2011.

Blessing E. M., Steenkamp M. M., Manzanares J., and Marmar C. R. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics (2015); 12(4): 825-836. Published online in September 2015.

Devinsky O. et al. Cannabidiol: Pharmacology and Potential Therapeutic Role in Epilepsy and Other Neuropsychiatric Disorders. Epilepsia (2014); 55(6): 791-802. Published online in May 2014.